There are many causes of pain in the right ankle when there is no sprain, and the most common causes are considered the following, including infectious inflammation, pulmonary infectious inflammation, metabolic diseases, bone and joint tumors, etc., as follows: 1. Infectious inflammation: caused by direct bacterial invasion of the joint, such as septic arthritis, ankle tuberculosis, osteomyelitis, etc., can lead to significant pain symptoms in the right ankle. 2, Non-infectious inflammation: Inflammation caused by long-term stress stimulation, such as ankle impingement syndrome, rheumatoid arthritis, osteoarthritis, traumatic arthritis, etc., can also lead to significant pain symptoms in the right ankle. 3. Metabolic diseases: For example, if a patient has gouty arthritis, it can also lead to significant pain symptoms in the right ankle and can be accompanied by morning stiffness. 4. Osteoarticular tumors: Common benign osteochondroma and malignant tumor will also lead to obvious pain symptoms in the right ankle.