The treatment of erythema nodosum includes general treatment and drug treatment. 1. General treatment: pay attention to rest during the onset of the disease, reduce walking, and elevate the lower limbs to help relieve the symptoms. 2. Drug treatment: glucocorticoid drugs, such as prednisone, can be used in combination as prescribed by doctor to inhibit the immune inflammatory reaction. When combined with streptococcal infection, you can follow the doctor’s instructions to choose sensitive antibiotics to treat, such as norfloxacin, ofloxacin and so on. When the pain symptoms are more serious, oral non-steroidal analgesic drugs, such as indomethacin, can be prescribed. If you suffer from erythema nodosum, it is recommended that you go to a regular hospital in time and be treated under the guidance of a doctor.