The New Coronavirus has been rampaging around the world for more than a year, and mainland China has made tremendous efforts and achievements in the war against the epidemic, with no New Coronavirus infections in the country for a long time. However, recently, the New Coronavirus has been gaining momentum in some foreign countries, and it is difficult for us to be alone in this global environment. As long as the NNV is not over, people should not let down their guard. Currently, there are three types of vaccines available in China: inactivated neo-coronavirus vaccine (Vero cells), recombinant neo-coronavirus vaccine (type 5 adenovirus vector) and recombinant subunit vaccine (CHO cells), of which one dose of recombinant neo-coronavirus vaccine (type 5 adenovirus vector), two doses of inactivated neo-coronavirus vaccine and two doses of recombinant subunit vaccine (CHO cells). Two doses of recombinant neocoronavirus vaccine (type 5 adenovirus vector), two doses of inactivated neocoronavirus vaccine, and three doses of recombinant subunit vaccine (CHO). Is there any special contraindication for neocoronavirus vaccination for brain tumor patients? This means that patients with brain tumors or not, who are allergic to the components of the neo-coronavirus vaccine, or who have had severe allergic reactions to previous vaccinations, as well as pregnant women, who have uncontrolled epilepsy or other serious neurological diseases, or who have fever or chronic diseases that are not well controlled, are not suitable for neo-coronavirus vaccination. Patients with brain tumors may be in different stages of brain tumor treatment, and need to be treated differently for neocoronavirus vaccination. Some brain tumors have not yet undergone surgery. Many of these patients are benign tumors under observation and regular review, and their condition is stable enough to receive the vaccine. Some brain tumors that have just undergone surgery can be vaccinated if they are stable and do not require follow-up treatment. However, if there are still fever and frequent seizures, it is not suitable to receive the New Crown vaccine immediately. If the brain is a malignant tumor, radiotherapy is required after surgery, which has a certain impact on the patient’s immune system, and the malignant tumor is in the stage of continued treatment and control, vaccination can be considered on hold. There are also some special cases of vaccination for the new crown vaccine, for example, vaccination is not recommended for people under 18 years old, and vaccination is also recommended for people over 60 years old if their health permits. As to whether other vaccines can be given at the same time, the recommendation is that there should be a 14-day interval, but if rabies vaccine or tetanus vaccine is needed for special reasons after the New Crown vaccination, it is necessary to give the vaccination as soon as possible even within 14 days because the lethality rate may be higher if these diseases are contracted. For whether or not to receive neo-coronavirus vaccination for brain tumor, besides considering the general contraindications and precautions for neo-coronavirus vaccination, special attention needs to be paid to evaluate several factors such as the stage and control of the brain tumor, the physical status of the patient and the subsequent treatment. Of course, the contraindications and precautions for neo-coronavirus vaccination are not unchanging, and may change as the universal vaccination campaign progresses.