Thyroid peroxidase antibody is a more sensitive indicator for detecting autoimmune thyroid disease, the danger of thyroid peroxidase antibody higher than 1000IU/ml is mainly seen in autoimmune thyroiditis, hypothyroidism, etc. The details are analyzed as follows. 1. Autoimmune thyroiditis: if the patient’s thyroid peroxidase antibody is higher than 1000IU/ml, it is necessary to improve the examination of thyroid function and thyroid ultrasound, if the thyroid function and thyroid ultrasound are normal, generally there is no need for treatment, and regular rechecking is enough. 2. Hypothyroidism: Autoimmune thyroiditis patients may be accompanied by hypothyroidism in the later stages. The main manifestations are lowered body temperature, fear of cold and fatigue. It can be treated with oral levothyroid hormone as prescribed by the doctor, and often requires lifelong medication. It is recommended that patients with thyroid peroxidase antibody higher than 1000IU/ml should consult the doctor and actively improve the examination, and follow the doctor’s instructions for treatment.