Children with persistent high fever need to choose the appropriate antipyretic method according to the degree of elevated temperature, such as physical hypothermia and medication to reduce fever. At the same time, the treatment of the cause of the disease is also the key to reduce fever. Fever is one of the most common clinical symptoms in pediatrics, and it is generally considered that a body temperature of 37.3-38 ℃ is low fever, 38.1-38.9 ℃ is moderate fever, 39-41 ℃ is high fever, and ≥ 41 ℃ is ultra-high fever. For children with fever but body temperature <38.5 ℃ can use warm water on the child's forehead, reduce the wearing of clothing and other physical methods of cooling, encourage children to drink more water, some children's body temperature can gradually decline; for children with body temperature ≥38.5 ℃ need to use antipyretic drugs such as ibuprofen, acetaminophen and other antipyretic treatments under the guidance of a doctor. At the same time for the cause of treatment is also very important for the recovery of body temperature, such as bacterial infection caused by respiratory tract infection, need to actively use antibacterial drugs such as cefaclor, cefdinir and other anti-infective treatment. If it is rheumatic immune disease, immunosuppressant treatment is needed; if it is hematological tumor-related disease, chemotherapy, bone marrow transplantation and other treatments are needed. Children with persistent high fever need to consult a doctor immediately and choose the appropriate treatment according to the doctor's advice to avoid further development of the disease. All of the above medications should be used under doctor's guidance, avoid self-medication.