Self-immune liver cannot be cured and currently only medication can be used to control the progression of the disease. It is an immune damage caused by some immune reactions due to the immune dysfunction of the body. Some patients can combine two or more diseases at the same time, which is called overlap syndrome. Clinically, the main manifestations of the disease are weakness, poor performance, abdominal distension, and yellow staining of skin mucosa. The clinical manifestations include weakness, poor appetite, abdominal distension, and yellowish staining of the skin mucosa. Liver function tests show elevated transaminases, elevated bilirubin, and decreased serum albumin. At present, there is no special drug treatment, can use ursodeoxycholic acid capsules, its development of the disease has a certain control, serious cases can be used as appropriate glucocorticoids, can also use some liver protection drugs, such as silymarin, ezetimibe, etc., late stage can cause liver failure, feasible liver transplantation treatment.