Headache in advanced stage of liver cancer may be related to brain metastasis, high blood pressure, cervical spondylosis, neuropathy headache and other aspects. 1. Brain metastasis: when liver cancer develops into advanced stage, brain metastasis may occur, which will damage central nervous system and cause headache. 2. High blood pressure: high blood pressure may be related to family heredity and excessive intake of food with high salt content, which will affect the blood supply to the brain and cause headache. 3. Cervical spondylosis: Cervical spondylosis is usually related to long-term low head work, etc., which may compress the local nerves and cause insufficient blood supply to the skull, and may be accompanied by the above mentioned conditions. 4. Neurogenic headache: neurogenic headache may be related to excessive mental pressure, insomnia, etc., which may damage local nerves and cause headache. For headache in advanced stage of liver cancer, it is necessary to consult doctor in time, listen to doctor’s advice, carry out relevant examination and treatment, so as to facilitate timely control of the condition.