Knee cartilage is slow to repair or even irreparable once damage occurs, therefore cartilage damage still has no better treatment in clinic and the best treatment does not exist. It can be relieved by weight control, medication and surgery. 1. Weight control: weight control can reduce the pressure of weight on knee cartilage, so as to avoid excessive stress impact on cartilage damage. 2. Medication: Non-steroidal anti-inflammatory drugs (NSAIDs) and chondro-nutritional drugs such as ibuprofen and aminoglycosan sulfate can be taken under doctor’s guidance to protect the cartilage, and sodium vitrate can be injected into the joint cavity to lubricate the cartilage so as to minimize the wear and tear. 3. Surgery: If the result is not good after the above treatment, knee joint surface replacement can be performed to relieve pain and improve the function of the knee joint, which is a better treatment for osteoarthritis caused by severe cartilage damage. Besides, in daily life, the cartilage wear and tear caused by knee flexion and extension can be avoided by changing the way of exercise, such as reducing the need to go up and down the stairs, etc., and the enhancement of muscle strength can also stabilize the knee joint and alleviate the symptoms in order to slow down the degeneration of the knee joint. It is recommended that patients seek timely medical attention and follow the doctor’s instructions, do not blindly use medication.