Breast puncture biopsy with necrotic tissue indicates the possible presence of mastitis, breast tumor, breast cancer and other conditions. 1. Mastitis: due to inflammation stimulation, an inflammatory lump will appear in the patient’s breast. With the development of the disease, the inflammatory mass will undergo tissue necrosis, thus forming a breast abscess. At this time, a breast puncture biopsy will show necrotic tissue. 2. Breast tumor: when an inflammatory lump appears in the breast, if it is not controlled in time, a tumor will be formed. At this time, there will be necrosis of the surrounding tissue. Necrotic tissue will be found when breast biopsy is done. 3. Breast cancer: When breast cancer progresses to a certain degree, local tissue infection and necrosis may occur, and at this time, there may be necrotic tissue in the breast puncture biopsy. It is suggested that when this situation occurs, timely diagnosis and treatment should be carried out, so as to prevent the condition from not being controlled and irreversible situation.