Vitiligo of the corners of the mouth can be treated with medications such as halometasone, phototherapy, and transplantation methods. Vitiligo is a common, acquired disease of the skin and mucous membranes with loss of pigmentation, which can involve hair follicles and is clinically manifested by white patches or (and) white hair. Vitiligo can involve any part of the body, and when it involves the mouth, it can be treated with medication, phototherapy, and transplantation therapy. 1. medication: for the smaller parts of the affected area can be under the guidance of the doctor external glucocorticosteroids such as halometasone treatment, but need to consider the skin atrophy and vasodilation and other adverse effects; also can take vitiligo pills, Bailing tablets for the internal use of medication, but need to pay attention to the contraindications of the use of drugs and adverse effects. 2. the use of light therapy: such as the use of NB-UVB and 308nmm excimer laser vitiligo treatment, but need to other parts of the protection, to avoid unnecessary damage. 3. If the involvement of the facial area is large, transplantation therapy can be used to transplant autologous epidermis or melanocytes into the depigmented area to achieve the purpose of repigmentation. Vitiligo at the corner of the mouth is recommended to go to the hospital in time, under the guidance of the doctor, do not self-medication.