Pearly papules are correctly referred to as penile pearly papules, and the condition is usually treated without topical medication and with topical antibiotics for localized secondary bacterial infections. Pearly penile papules are characterized by the appearance of translucent, pearly papules on the coronal margins and coronal sulcus of the penis, and are usually the result of physiologic variation or local irritation. The disease is benign through, usually does not cause harm to the health of the organism, usually do not need special treatment. The long foreskin and poor hygiene of private parts are the risk factors of the disease, easy to combine with bacterial infection, secondary infection can be treated with topical antibiotics. Commonly used drugs are erythromycin ointment, fusidic acid cream, mupirocin ointment and so on. The use of specific drugs need to consult the doctor, it is recommended not to abuse the drug, so as to avoid drug resistance. If the patient has the need to remove for appearance reasons, it is recommended to go to the dermatology department of a regular hospital, and under the guidance of the doctor to remove by laser, freezing and other physical means.