The vast majority of HPV 16 and HPV 18 positives will turn negative, but a small percentage will develop a persistent infection. Persistent infection can lead to precancerous cervical lesions and even cervical cancer. Therefore, patients with high-risk HPV infection should undergo colposcopy and decide on the next step of treatment based on the results of the examination. In addition, patients with high-risk HPV infection should be followed up clinically so that they can find out when the cervical epithelium becomes lesioned in time and be given certain treatment according to the degree of lesion, which can effectively prevent the occurrence of cervical cancer.