Is nerve invasion by poorly differentiated gastric cancer serious?

Hypofractionated gastric cancer with nerve invasion is relatively more serious. Gastric cancer includes low differentiation, middle differentiation, high differentiation and undifferentiated according to the degree of cell differentiation, among which low differentiated and undifferentiated tumors are very malignant, and they are especially prone to recurrence and metastasis after surgery. Tumor cells found to have neurological invasion are also relatively serious and are one of the indications of high risk. It is possible that nerve invasion is found in the specimen, or the tumor has already invaded the retroperitoneal nerves, and it may be a stage IV tumor, which means that the tumor has already invaded beyond the plasma membrane. Patients with more advanced tumor staging are prone to recurrence and metastasis after surgery, abdominal pain as well as incomplete intestinal obstruction, and tumor dissemination and implantation metastasis in the abdominal cavity.