Patients are not advised to take azithromycin and levofloxacin together. Azithromycin belongs to macrolide antibiotics, mainly against aerobic gram-positive and aerobic gram-negative bacteria as well as anaerobic bacteria and special pathogens, such as chlamydia, mycoplasma, legionella and so on. Levofloxacin belongs to the quinolone antibiotic class and is effective against most gram-negative bacteria as well as sensitive gram-positive bacteria and atypical pathogens such as Mycoplasma, Chlamydia and Legionella. The antibacterial spectrum of levofloxacin can mostly cover azithromycin, i.e., one antibiotic can be used. Both drugs have irritating side effects, such as gastritis, esophagitis, pancreatitis, and tongue inflammation. If the two drugs are applied at the same time on the stomach irritation is greater, so that the incidence of adverse reactions will increase, and both drugs have a certain degree of liver toxicity, if taken together may lead to liver damage, so it is recommended that patients do not take two drugs together. The above two antibiotics should be used under the guidance of a physician, in which levofloxacin is prohibited for children under 18 years of age, if there is discomfort, it is recommended to consult a doctor in a timely manner, under the guidance of a professional doctor to clarify the cause of the targeted treatment, the individual should not blindly use the drug, in order to avoid adverse consequences.