Those who do not have drug contraindications can take rivaroxaban and metformin together for treatment, but please use the drug under the guidance of a doctor. Metformin is an insulin sensitizer, which can inhibit intestinal glucose absorption, hepatic gluconeogenesis and output, increase the uptake and utilization of glucose in tissues, improve insulin sensitivity, and have the effect of lowering hyperglycemia. It can be used to treat patients with type 2 diabetes mellitus whose blood sugar cannot be well controlled by dietary control and appropriate exercise. It is contraindicated in patients with allergy to this drug, heart failure, severe infection and trauma, metabolic acidosis, acute alcoholism, etc. Rivaroxaban has an anticoagulant effect and can be used to prevent deep vein thrombosis and pulmonary embolism in patients after knee or hip replacement, and can also be used to prevent stroke in patients with non-valvular atrial fibrillation, etc.; it is contraindicated in patients who are allergic to this drug, who have significant active bleeding, who are pregnant and breastfeeding women, or who have lesions or conditions that pose a significant risk of hemorrhage. So those who do not have the above contraindications can be treated with rivaroxaban and metformin, but please use the drug under the supervision of a doctor. And, adverse reactions such as hypoglycemia, hepatitis, nausea, vomiting, diarrhea, bloating, urticaria, and fatigue may occur after using metformin. Adverse reactions such as bleeding, dizziness, headache, nausea, abdominal pain, and kidney damage may occur with the use of rivaroxaban. Patients requiring coadministration of rivaroxaban and metformin therapy should use the medication under the supervision of a doctor.