What is the prognosis for epilepsy?

  Epilepsy is a treatable disease and the prognosis estimate for epilepsy is related to many factors, such as seizure type, etiology, seizure frequency, age of onset, scalp EEG performance, and response to antiepileptic drugs. It has been investigated that 27.1% of epilepsies remit spontaneously for more than 5 years.  Typical aphasic seizures: especially those with onset before the age of 10 have the best prognosis, with remission rates up to 80%.  The prognosis for partial seizures is worse for psychomotor seizures and the worst for infantile spasms.  The average life expectancy of epileptic patients is not short, but the prognosis is poor if certain known organic brain lesions such as brain tumors, penetrating brain malformations, and brain atrophy are seen.  The earlier the onset of epilepsy in children, the worse the prognosis, and in those with onset before the age of 1, seizures are often difficult to control and the prognosis is poor. Late onset epilepsy, without organic damage such as brain tumors, has a better prognosis.  The prognosis is better for those whose seizures are treated early, poorer for those who start treatment 5 years after onset, and better for those whose seizures are quickly controlled by a single conventional dose of antiepileptic drugs.  The higher the frequency of seizures, the worse the prognosis.  A normal or near-normal scalp EEG is good evidence of prognosis. An abnormal scalp EEG with bilateral synchronous discharges has a better prognosis, while an abnormality in one hemisphere or diffuse abnormality has a worse prognosis. Temporal and frontal regions have a poor prognosis, and temporal spiking waves in children indicate a good prognosis.  There is not complete agreement between scalp EEG and seizures. Clinical seizure cessation with abnormal scalp EEG is not a sign of prognosis.  The possibility of sudden death in individual cases, for which no cause can be identified, may be presumed to be related to sudden and severe intracranial pressure increase, acute adrenal insufficiency or vegetative neurological paresis or acute loss of brainstem function causing respiratory or blood circulation disturbances.  With the development of epilepsy surgery, some complex partial epilepsies and refractory epilepsies that cannot be controlled by certain drugs have improved significantly with appropriate management in some cases, with seizure-free and rarely occurring cases between 30% and 70%.