Persistent vague pain in the stomach with ineffective medication may be the result of an unknown diagnosis of stomach disease, without reasonable treatment, or may be the result of early acute appendicitis, pancreatitis, myocardial infarction, etc. It is necessary to actively seek medical advice to clarify the cause and give reasonable treatment. Common causes and treatment methods 1, gastric disease: such as persistent vague pain in the stomach, no obvious effect of medication, first of all, should clarify the cause, perform gastroscopy as well as respiratory test examination, if the diagnosis of Helicobacter pylori infection, should use the quadruple standard treatment program, such as the diagnosis of gastric cancer, recommended surgery, if other diseases, also need to actively treat; 2, early acute appendicitis: due to inaccurate positioning of visceral nerves, involved and performance epigastric pain, similar to the symptoms of gastritis, if accompanied by metastatic right lower abdominal pain with fixed pressure points, it is recommended to go to the hospital for abdominal ultrasound and routine blood tests to clarify the diagnosis, treatment is recommended to use broad-spectrum antibiotics such as cephalosporins combined with metronidazole, surgical treatment is recommended laparoscopic minimally invasive removal of the appendix; 3, pancreatitis: pancreatitis attack involving the gastrointestinal tract will appear symptoms of stomach pain, manifested as severe The treatment can be given to drugs that inhibit the secretion of pancreatic enzymes, such as octreotide; 4, myocardial infarction: myocardial infarction can radiate to the stomach in severe cases, causing discomfort, such as suspicion of this condition can go to the hospital to do electrocardiogram, blood sampling troponin. Because the cause of the disease is more complex, after the diagnosis should be symptomatic treatment, usually pay attention to avoid excessive exertion and bowel movements, such as force. It is recommended that patients should seek medical attention in a timely manner to clarify the cause of the disease and should not delay, so as to avoid the continued progress of stomach or pancreatic, appendix, or even heart disease, which may aggravate the discomfort. Daily attention to diet, eat more light, easy to digest food, such as porridge, noodles, and fresh vegetables and fruits, should not eat chili, mustard and other spicy, stimulating food.