Persistent vague pain in the stomach is commonly associated with poor diet and gastrointestinal disorders. In addition, diseases of the gallbladder, pancreas and heart can radiate to the stomach and cause the symptoms of persistent vague pain in the stomach. Therefore, we should pay attention to timely examination at the hospital, and treat the cause of the disease through gastroscopy, abdominal ultrasound, abdominal CT, blood tests, electrocardiogram and other tests. First, improper diet too much or mixed diet, such as eating spicy and irritating, greasy food, as well as excessive alcohol consumption, can cause increased secretion of gastric juice, stimulating the gastric mucosa and causing gastric mucosal ulcers, thus causing stomach pain, which may be accompanied by nausea, vomiting, gas and other symptoms. It can be relieved by adjusting diet, such as diet should be light and easy to digest, such as porridge, noodles, eggs, milk, etc. Avoid eating raw, cold, hard and spicy food. Second, gastrointestinal diseases 1, acute gastritis: inflammation stimulates the gastrointestinal mucosa, which in turn leads to persistent hidden pain in the stomach. Patients should rest in bed and eat lightly or fast appropriately. Those with obvious vomiting and diarrhea should pay attention to timely replenishment of electrolytes and water. Use gastric mucosal protective agents, such as aluminum thioglycollate, and the acid suppressant pantoprazole under the guidance of a doctor. Antibiotics, such as levofloxacin, should be given to those with bacterial infections. 2. Gastric ulcer: persistent hidden pain in the stomach after eating, relieved 1-2 hours after meals, accompanied by acid reflux, heartburn, burping, belching, nausea, vomiting, and other symptoms. Patients should pay attention to rest, avoid spicy and stimulating food, and do not drink coffee and strong tea. Avoid taking non-steroidal anti-inflammatory drugs such as ibuprofen and aspirin. Cimetidine, proton pump inhibitors, bismuth and other drugs can be used for treatment as prescribed by the doctor. If the ulcer is heavy and serious complications occur, surgery should be performed; 3. Duodenal ulcer: H. pylori infection and the application of non-steroidal anti-inflammatory drugs stimulate and damage the gastrointestinal mucosa, which can result in persistent hidden pain in the stomach. Treatment can be taken to eradicate H. pylori quadruple therapy, namely proton pump inhibitors + two antibacterial drugs + bismuth, and drug therapy to inhibit gastric acid secretion, such as pantoprazole, omeprazole, etc. If necessary, duodenal perforation repair is feasible; 4. Gastric cancer: progressive gastric cancer may present with discomfort such as epigastric pain and weight loss, which often occurs in people aged 40-70. It is usually treated by surgery, combined with perioperative radiotherapy, chemotherapy and biological targeted therapy. Gallbladder disease 1. Gallbladder inflammation: It is manifested as paroxysmal colic in the right upper abdomen, which gradually develops into continuous distension and pain, often after a full meal or eating greasy food, and the pain may radiate to the right shoulder and back, and patients may have continuous vague pain in the stomach. Cholecystitis can be treated by medication and surgery, such as applying drugs such as atropine and pethidine to relieve spasm and analgesia, as well as biliary drugs such as magnesium sulfate and dehydrocholic acid, as prescribed by the doctor. If necessary, cholecystectomy is feasible; 2. Gallstone disease: manifested as vague pain in the upper abdomen, sometimes accompanied by fullness and discomfort, acid reflux and other symptoms. Patients with gallstones can take dehydrocholic acid tablets or ursodeoxycholic acid tablets to promote bile discharge and control inflammation. Surgical treatment such as laparoscopic cholecystectomy, open cholecystectomy, common bile duct dissection and T-tube drainage can also be taken according to the condition. Fourth, pancreatic diseases with hidden pain in the stomach are commonly associated with pancreatitis, mostly after drinking or overeating, often accompanied by nausea, vomiting and abdominal distension, and in severe cases, multiple organ failure can occur. Patients should pay attention to fasting and parenteral nutrition or jejunal nutritional support, use drugs that inhibit pancreatic secretion and pancreatic enzyme activity, such as omeprazole and pantoprazole, etc. If necessary, antispasmodic and analgesic drugs can be applied to relieve pain, such as scopolamine and atropine. Quinolones and cephalosporins can be used to prevent infection, and severe cases should be treated surgically. V. Others include involvement pain of heart disease and central abdominal pain. For patients with epigastric pain an electrocardiogram must be performed to exclude diseases such as acute myocardial infarction. Central abdominal pain is usually caused by psycho-psychological factors, the excitation foci from the center cause pain, abdominal no etiology can be found, mostly accompanied by a variety of clinically seen mental abnormalities, need to consult the examination before taking the appropriate treatment methods.