Sudden and severe pain in the stomach is usually due to a sudden and more intense contraction of the stomach, or due to stimulation of the damaged gastric mucosa by digestive juices, which in turn causes severe pain in the patient’s stomach. Hot water bags or warm towels can be used to apply local heat to promote blood circulation and relieve spasm symptoms. Drugs that antispasmodic, promote gastrointestinal motility and protect gastric mucosa, such as belladonna combination, domperidone and thioglycollate, can also be taken under the guidance of a doctor for treatment. Those with significantly increased gastric acid can be treated with proton pump inhibitors, which can be seen in gastritis, gastrointestinal perforation, reflux esophagitis, gastric cancer and other lesions, which need to be treated for the cause after clarifying the etiology. Common conditions are as follows: 1. Gastritis: Sudden and severe pain in the stomach caused by factors such as bacterial infection, physical or chemical stimulation, and various stress reactions stimulating the gastrointestinal tract. Treatment should pay attention to avoiding triggering factors and treating symptomatically for different types of gastritis. Analgesic drugs such as atropine, probenecid and belladonna combination are available for painful episodes. Proton pump inhibitors, such as rabeprazole, lansoprazole, omeprazole, etc., can be used to suppress stomach acid. For milder symptoms, H2 receptor blockers, such as metformin, ranitidine, aluminum hydroxide amine, etc., can be used. Mucosal protective agents can be given to those with low gastric acid. Those with dyspepsia can add pancreatic enzyme tablets, multi-enzyme tablets and other digestive aids. If H. pylori is found in gastric mucosal biopsy, H. pylori eradication treatment should be given; 2. Reflux esophagitis: reflux of gastric and duodenal contents into the esophagus, causing acid reflux, nausea, vomiting and other symptoms, and when the symptoms worsen, sudden and severe pain in the stomach can occur. Treatment should pay attention to reduce reflux, reduce gastric secretion irritation and erosion, can follow medical advice to apply acid-suppressing agents to neutralize gastric acid, such as omeprazole, pantoprazole, etc. Gastrointestinal function can be improved by applying drugs that promote gastric motility, such as domperidone and etopride. If necessary, surgical repair of hernia fissure, anti-reflux, and correction of esophageal stricture treatment can be performed; 3. Gastrointestinal perforation: Gastrointestinal perforation caused by peptic ulcer, intestinal typhoid, gastrointestinal malignancy, Crohn’s disease, trauma, etc. Patients can manifest as sudden and severe pain in the stomach. Once a perforation of the digestive tract occurs, surgery should be performed immediately to repair the perforation or remove the diseased intestinal segment to quickly terminate the continued leakage of gastrointestinal contents into the abdominal cavity. Simultaneously administer supportive treatment such as fluid, blood transfusion, anti-shock and anti-infection to maintain stable vital signs, and carry out etiological treatment after the vital signs are stabilized. In the process of medical treatment, attention should be paid to diet, usually you can eat, such as millet porridge, noodles and other light, easily digestible food, avoid eating spicy and stimulating, cold food. At the same time, you should eat less and more meals and pay attention to keeping the abdomen warm to prevent catching cold.