Olmesartan ester and candesartan ester which is the best can not be judged, it depends on the patient’s indications, to choose the right drug for the patient under the guidance of the physician. Olmesartan ester and candesartan ester are both angiotensin II receptor antagonists, the main indication is hypertension, both have good antihypertensive effect, the mechanism of action is similar, it is not possible to determine the good or bad of the two drugs, it depends on the patient is more suitable to take the drug. The adverse of olmesartan ester are bronchitis, malignant, dyspepsia, chest pain, rash, etc. Allergy to the drug components, diabetic patients who are taking aliskiren, and patients with severe liver damage are prohibited. Adverse effects of Irbesartan are postural hypotension, postural dizziness, myalgia, arthralgia, etc. It is contraindicated in women who are allergic to the components of the drug, in advanced stages of pregnancy, and during lactation. Patients should choose olmesartan and irbesartan treatment under the guidance of the physician, choose the appropriate drug, and not blindly use the drug on their own.