With the development of society and the improvement of medical treatment, many diseases that were considered undiagnosable in the past can now be diagnosed clearly and treated with good results. Pituitary dwarfism (GHD) due to growth hormone deficiency is one of the most common causes of childhood dwarfism, accounting for 3-30% of dwarf children. It directly endangers the health and quality of children. Half of them are often combined with other pituitary hormone deficiencies as total hypopituitarism, also known as multiple pituitary hormone deficiency (MPHD) or combined pituitary hormone deficiency (CPHD), which has more than one other pituitary anterior or posterior hormone deficiency in addition to GHD, and is more harmful than simple GHD. For example, short stature, vulvar dysplasia (small penis, cryptorchidism, small testes or scrotal dysplasia), secondary hypothyroidism, adrenal insufficiency, etc., and even convulsions and crises may occur in emergency situations, the deficient hormones must be fully replenished in order to achieve good treatment results. The various pituitary hormones often have synergistic or antagonistic effects on each other. In children with MPHD, cortisol (Cor) deficiency and growth hormone (GH) supplementation alone can lead to adrenal crisis, while excessive cortisol supplementation can inhibit growth. Thyroid hormones have synergistic effects with GH, and normal thyroid function is a prerequisite to ensure the effect of GH. Sex hormones are closely related to accelerated growth during puberty, and small penis and testicles are also time-sensitive to treatment, with poor results if treated too late. If we understand that other hormones are not secreted enough, hormone replacement therapy (HRT) can help to enhance the effect of GH treatment in children with MPHD and reduce sexual infertility in adulthood, etc. We have treated thousands of patients who have grown to over 175 cm in height.