Craniopharyngioma post-surgery urolithiasis, repeated treatments with no results , what is the best way to cure anterior pituitary hypopituitarism? Generally, hypopituitarism of the anterior pituitary caused by craniopharyngioma itself or by surgery requires cortisol hormone, thyroid hormone, and sex hormone replacement therapy, and lifelong replacement therapy. Unless the tumor has a small effect on anterior pituitary function or the intraoperative injury is transient, the medication may be taken for a shorter period of time. Periodic review of blood and urine cortisol, thyroid function, and gonadal function may clarify the need for lifelong treatment.