Pituitary stalk interruption syndrome (PSIS) refers to a clinical series of symptoms caused by pituitary stalk deficiency combined with pituitary ectasia, where the hypocretic hormones are not delivered to the pituitary gland through the pituitary stalk, suggesting congenital and permanent growth hormone (GH) deficiency. Clinical manifestations include delayed growth and sexual development, which can also cause multiple hormone deficiencies. Adrenal crisis can occur when adrenocorticotropic hormone is insufficient or absent, involving multiple systems, mainly manifesting as dehydration, decreased blood pressure, postural hypotension, deficiency, anorexia, vomiting, depression, drowsiness and even coma. Zhang Xia’er, Department of Pediatrics, The First Affiliated Hospital of Henan College of Traditional Chinese Medicine The incidence of PSIS is very low, and research on its pathogenesis is inconclusive. Mathematicians believe that the appearance of the disease is related to damage to the hypothalamus a pituitary region, such as abnormal perinatal factors such as breech pretermination or foot pretermination, abnormal delivery, craniocerebral trauma or skull base surgery, which tear the otherwise normally developed pituitary stalk. Intrauterine or postpartum asphyxia and abnormal cranial hypoperfusion can also cause damage to the pituitary gland and pituitary stalk. There is much uncertainty about the genetic factors involved in the development of PSIS, so further research is needed to determine whether PSIS is genetically related. When the pituitary stalk is transected, the neural tissue of the stump of the pituitary stalk above the severed end expands, forming an ectopic posterior pituitary lobe. The formation may be related to the inability of ADH secreted by the hypothalamus to be transmitted through the pituitary stalk to the normal posterior pituitary lobe. The characteristic imaging manifestations of PSIS include: (1) complete absence or significant thinning of the pituitary stalk; T1WI normal posterior pituitary fossa and small patchy or nodular high signal of the ectopic posterior pituitary lobe can be seen in the funnel fossa or median elevation of the third ventricle, which is a specific sign of PsIS. This is a specific sign of PsIS. It is also the main point of diagnosis; (3) the anterior pituitary lobe is atrophied and thinned to varying degrees, and the structures are not visible or even disappear.