Q: Everyone says that taking hormones will make me fat, so I’ll try not to take any medication after surgery. A: Endocrine-related hypofunction generally requires hormone replacement therapy, which varies slightly depending on age, gender and treatment needs. Endocrine is a hormone-related disease, and there are dozens of hormones. The hormones that people often refer to are glucocorticoids. Glucocorticoids taken in excess of physiological doses can lead to weight gain, full moon faces, buffalo backs, centripetal obesity, polycythemia and even hypertension, diabetes, osteoporosis, and other complications. This usage is often used in immunology to treat immune-related diseases. Glucocorticoid replacement therapy in endocrinology, on the other hand, is a dose that the patient otherwise lacks and needs to supplement, usually 1/4 tablet to 1 tablet, depending slightly on the patient’s condition. Such doses do not cause the symptoms and complications described above. Instead, untreated treatment can induce life-threatening emergencies such as shock infections. Other common hormone replacements include: thyroxine, antidiuretic hormone, growth hormone, male hormone, female hormone, etc. In physiological doses, they also do not cause weight gain, and some hormones can reduce weight after use. Therefore, hormones that need to be replaced must be supplemented; certain hormones are selectively supplemented according to conditions; different age groups need different hormones and should be adjusted accordingly. As long as one suffers from endocrine diseases, one must follow up for life, including after endocrine tumor resection, because endocrine tumors are often multiple and the age of onset varies.