The difference between chronic kidney disease stage III and IgA nephropathy grade III can be analyzed in terms of causes as well as symptoms. 1. Causes (1) Chronic kidney disease stage III is a stage of chronic kidney disease, and the causes are usually related to glomerulonephritis, hypertension, diabetes mellitus, polycystic kidney, systemic lupus erythematosus and other diseases. (2) IgA nephropathy stage III is a stage of IGA, the cause is still unclear, it may be related to food antigen or viral antigen, and may be related to the abnormal regulation of the immune system. 2. Symptoms: In addition to symptoms of primary diseases such as hypertension, diabetes mellitus, skin rash, arthralgia, etc., symptoms of chronic kidney disease stage III generally include swelling of limbs, anemia, calcium and phosphorus disorders, acidosis, ionic disorders, etc. Symptoms of IgA nephropathy stage III generally include hematuria, urinary protein, edema, etc., and the disease progressively develops into chronic kidney disease stage III. In addition, whether it is IgA Nephropathy Grade III or Chronic Kidney Disease Stage III, the harm is relatively large, it is recommended that the patient timely regular hospital consultation, follow the doctor’s instructions for standardized treatment.