A couple who has a normal regular sexual life without using contraception and does not conceive within one year is said to be infertile. First of all, couples preparing for pregnancy should know that the percentage of women conceiving naturally in one menstrual cycle is 20-25%. The cumulative pregnancy rate within one year is about 85%, and the remaining 15% is infertility, which has been gradually increasing in recent years. Understanding this, many couples preparing for pregnancy can relax and not expect to conceive in a month, and if they don’t conceive in that month, they will start thinking about it and then it will further affect their normal life and conception. In addition, couples who are preparing for pregnancy should know that during the natural conception process, bad emotions such as chronic anxiety, depression or fear of anxiety can be transmitted through the nerves to the brain, affecting normal ovulation and the transport of embryos from the fallopian tubes to the uterine cavity. Certain stress factors may also lead to disturbances in the immune status of the body, interfering with the implantation of the embryo and affecting implantation. It is also important to note that a poor state of mind affects the outcome of IVF treatment. If a couple is finally told that they must undergo IVF after systematic and regular examination and treatment, they must be open and maintain a good state of mind because psychological factors have an impact on the success rate of IVF. If a patient is doing well in all stages of IVF, then consider failure to be related to and psychological stress. Many patients admit to being very nervous and restless during the two weeks after embryo transfer while waiting for the results, even affecting their sleep and diet. The last thing to tell is to be honest even if by all means you get pregnant. Research shows that women who are emotionally tense and not relaxed during the first three weeks of pregnancy have more than three times the risk of miscarriage than those who are not tense. When a person is emotionally tense for a long time, it can lead to contraction of the uterus, contracture of the fallopian tubes, abnormal secretion of cervical mucus, etc., which may eventually lead to miscarriage. Adverse psychological factors such as tension and depression can affect the endocrine-plant nervous system-gonadal hormone axis, causing hormonal disorders in the organism, resulting in lower progesterone levels in the body and poor placental development, all of which are detrimental to embryonic development. In addition, the uterus is in a hypersensitive state, and a very light stimulus can induce uterine contraction, thus inducing miscarriage. In clinical practice, we have seen some infertility patients who can easily get pregnant after treatment, but they are worried about whether the embryo is good or not, whether it will be deformed, and so on. In this situation, the embryo stops developing or miscarries. After getting pregnant again, the fear becomes even greater, forming a vicious circle. In summary, although infertility is not a fatal disease, it has serious negative impact on the physical and mental health of patients, especially in families with strong family values and deep-rooted ideas of heirarchy, and in serious cases, it can cause the couple’s relationship to break up and family discord. Therefore, when patients learn that they are suffering from infertility, they should face this fact frankly, adjust their mindset actively, reduce their stress, and seek advice and help from doctors while talking to others about their inner worries to divert excessive attention from infertility. At the same time, the patient’s family members should also give the patient full respect, understanding and care, actively encourage and help the patient, and create a relaxed family atmosphere.