What are the glycosidase inhibitors

Glycosidase inhibitors are a class of drugs commonly used in the treatment of diabetes. The main glycosidase inhibitors commonly used in clinical practice are acarbose, voglibose, miglitol, etc. Glycosidase inhibitors are used to lower blood glucose by inhibiting the activity of intestinal glycosidases and inhibiting the absorption of intestinal carbohydrates. Glycosidase inhibitors have the following characteristics: i. They mainly lower postprandial blood glucose and have less effect on fasting blood glucose. Second, it does not increase the secretion of insulin, so hypoglycemia will not occur when applying glycosidase inhibitors alone. Third, glycosidase inhibitors can be combined with sulfonylureas or biguanides, and insulin. Fourth, glycosidase inhibitors such as acarbose, voglibose and miglitol may cause gastrointestinal symptoms such as abdominal distension, diarrhea and abdominal pain.