Methotrexate is used for the treatment of hematological tumors, or for the conservative treatment of ectopic pregnancy. The most common side effects are poor gastrointestinal function, nausea and vomiting, loss of appetite, and gastrointestinal bleeding. In addition, common side effects can damage liver function and kidney function, resulting in elevated liver enzymes, elevated blood uric acid, and elevated creatinine. Long-term application of methotrexate may also affect the function of the hematopoietic system. Therefore, it is important to check the liver function, kidney function and blood count during the drug application.