The “dual DA and 5HT receptor” theory has been discredited. There is a theory that inhibiting 5HT receptors does not have a significant effect on symptoms, and the “dual DA and 5HT receptor” theory has been discredited, which is not credible. There are several theories about the etiology and pathogenesis of schizophrenia, among which neurotransmitter research is mainly based on the hypothesis of dopamine hyperfunction and glutamate system imbalance, and antipsychotic drug treatment is based on the receptor theory, where drugs act on dopamine D2 receptors to exert antipsychotic effects, 5-HT has a regulatory effect on DA neurons, 5-HT inhibits DA release in the limbic and nigrostriatal regions of the midbrain, and 5-HT2A may be atypical. , 5-HT2A may be an important site of action for atypical drugs, and 5-HT2A antagonists may attenuate the inhibitory effects of chronic antipsychotic treatment on DA, thereby enhancing DA function in certain brain regions to alleviate negative symptoms and extrapyramidal responses.