Neonatal diarrhea should not be rushed to stop diarrhea, newborns should avoid the use of antidiarrheal drugs, treatment should be adjusted diet, prevention and correction of dehydration, rational use of medication. Newborns with diarrhea should continue to diet to meet physiological needs, according to the actual situation of the calculation of its required solution, such as the emergence of convulsions can be supplemented with calcium or magnesium. For different causes of diarrhea follow the doctor’s instructions to choose the appropriate drugs, such as Escherichia coli caused by the choice of antibiotics such as ceftazidime treatment; the use of probiotics (such as bacillus subtilis bacillus granules) to adjust the intestinal bacterial imbalance; the choice of montmorillonite powder intestinal mucosal protective agent to enhance the barrier function. Newborns with diarrhea should seek medical attention in order to clarify the cause of the disease and choose the appropriate treatment under the guidance of professional doctors.