Irbesartan and enalapril are both primarily used for the treatment of hypertension and cannot be compared for their effectiveness in reducing proteinuria. Enalapril is an angiotensin converting enzyme inhibitor. It is used to treat essential hypertension. In hypertensive patients, enalapril maleate reduces prone and sitting blood pressure without causing compensatory heart rate acceleration. On hemodynamic examination, enalapril maleate significantly reduces peripheral vascular resistance. Dizziness, headache, fatigue, and cough may occur after administration; reduce dosage if necessary. If leukopenia occurs, the drug needs to be discontinued. It is contraindicated in people who are allergic to enalapril maleate or other ACEI drugs or any of its components, or in people with renal artery stenosis. Use with caution in pregnant and lactating women. Irbesartan is used in the treatment of hypertension. It is an angiotensin II receptor inhibitor that inhibits the conversion of AngI to Ang II and specifically antagonizes AT1 receptors. Postural vertigo, postural hypotension, and skeletal muscle pain may occur after administration. It is contraindicated in persons with known hypersensitivity to the components of the product, in the 4th to 9th month of pregnancy, and during lactation. In addition, patients are advised to take both medications under the supervision of a doctor and not to use them privately.