Glucosamine sulfate is mainly used for the treatment of primary and secondary osteoarthritis. After administration, patients may experience the following side effects: 1. Mild gastrointestinal discomfort, such as nausea, constipation, bloating, abdominal pain and diarrhea, mild headache, fatigue and sleepiness, and occasionally mild drowsiness. 2. Some patients may experience allergic reactions, including rash, itching and skin erythema. 3, hair loss, bronchial asthma and elevated blood sugar have been reported. Therefore, it is important to keep an eye on the medication and seek medical attention for any abnormal manifestations. It is best to take the drug with or after meals to reduce gastrointestinal discomfort, especially in patients with gastric ulcers. Since this drug has been reported to cause elevated blood glucose or blood lipids, it should be used under medical supervision for patients at risk of diabetes or cardiovascular disease, and monitoring of blood glucose or blood lipids is recommended. Patients with asthma should discontinue the drug in the event of worsening asthma symptoms while taking it.