Itching all over the body after exercise requires careful observation of the appearance of the itchy skin all over the body. If there are red or white bumps on the surface of the skin, it may be cholinergic urticaria, also known as athletic urticaria. It is triggered by the body’s intolerance to its own secretion of acetylcholine, and can be treated with oral cetirizine tablets or loratadine tablets, which can effectively make the symptoms of generalized itching disappear, and make the raised skin tingles subside, so as to achieve the therapeutic purpose. It should be noted that oral administration of thymopeptide enteric-coated tablets to improve immunity in daily life can reduce the probability of recurrence of this disease, reduce exercise and sweating, and gradually increase the amount of exercise only after the disease has fully recovered.