Male perineal nodules may be penile cancer, condyloma acuminatum of penis, cavernous sclerosis, and the corresponding treatments are surgery, radiotherapy, laser, freezing and antiviral drugs, physical and surgical treatments. 1. Penile cancer: local pathological biopsy should be carried out, and after diagnosis, according to the scope of tumor, partial or total excision of penis and urethrostomy in perineal area should be carried out. After operation, adjuvant radiotherapy or chemotherapy can be used. 2. Penile condyloma acuminatum: According to the size and number of condyloma acuminatum distribution, you can choose laser or cryotherapy. If the warts are widely distributed on the foreskin, they can be removed together with the foreskin, followed by antiviral treatment, such as interferon injection, combined with topical interferon gel. 3. Cavernous hardness: Vitamin E or vitamin C can be used as antioxidant, and physical methods such as thermostatic water massage and negative pressure suction can be used to make the penis passively erect, improve the blood operation of the cavernous body, and accelerate the hardness to subside and be absorbed. Severe cases can be treated with penile prosthesis implantation surgery. Male perineal nodules suggest timely consultation, clear cause, treatment, specific medication should follow the doctor’s instructions.