High serum indirect bilirubin is mainly due to increased destruction of red blood cells or impaired uptake of indirect bilirubin by the liver. Bilirubin is a product of the metabolism of aging red blood cells, and total bilirubin consists of indirect bilirubin and direct bilirubin, which is metabolized by the liver and converted into direct bilirubin, and then formed into bile and excreted through the biliary tract. Indirect bilirubin can be elevated due to massive necrosis of hemoglobin cells or impaired hepatic uptake of indirect bilirubin. It is commonly seen in hemolysis, hepatitis, cirrhosis and liver cancer. Symptoms of high indirect bilirubin are mainly jaundice, such as yellowing of the sclera, skin, urine and mucous membranes. It is recommended to actively seek medical treatment, complete the examination, clarify the cause and diagnosis, and standardize the treatment under the guidance of physicians to avoid delaying the condition.