Diagnosis of fatigue is based on the patient’s complaints, clinical symptoms, clinical manifestations, auxiliary examinations, and then differential diagnosis can be made to make a clear diagnosis of fatigue. Usually, these patients will have complaints such as weakness, low immunity, chest tightness, shortness of breath, etc. Relevant examinations such as respiration, blood pressure, pulse rate, oxygen saturation, etc. should also be completed. For example, high or persistently low blood pressure is a typical clinical symptom of overwork, for physical examination of overwork there will be bradycardia or tachycardia, arrhythmia, low heart sound, heart enlargement of the cardiovascular system and other obvious symptoms. For auxiliary examination, patients will also appear such as electrocardiogram changes, cerebrovascular transcranial Doppler will show that the cerebrovascular blood supply is incomplete, and blood routine usually shows mild anemia, all of which can be used to diagnose excessive fatigue.