Rivaroxaban is an anticoagulant whose most common adverse effect is bleeding, so coughing up blood may occur after oral administration of rivaroxaban. Rivaroxaban is mainly used for the treatment of deep vein thrombosis and pulmonary embolism in adults, in adult patients undergoing elective hip or knee replacement surgery, and in adult patients with non-valvular atrial fibrillation with one or more risk factors. It is contraindicated in women with significant active bleeding, coagulation abnormalities, pregnant and lactating women. Since rivaroxaban has a good anticoagulant effect, it may cause occult or overt bleeding in some tissues or organs, commonly including bleeding from gums, gastrointestinal bleeding, bleeding from genitourinary tract, etc. Symptoms such as blood in sputum due to severe coughing may also occur. If severe bleeding occurs, rivaroxaban must be discontinued. In addition, cough bleeding may also be present with respiratory pathology and is not necessarily caused by adverse drug reactions. If you have symptoms of cough bleeding, it is recommended that you consult a doctor in time to improve the examination and treatment under the doctor’s guidance in order to achieve the best therapeutic effect.