Congenital megacolon is somewhat hereditary.
Congenital megacolon is one of the digestive tract malformations, also known as anaplastic ganglion cell disease, which is a common malformation in the development of the pediatric digestive tract.
For familial and long segmental congenital megacolon, it is common to have a mutation in the RET gene in the chromosome. Its mutation causes disruption of the information conduction pathway, leading to abnormalities in neural crest cell migration and differentiation in the embryonic stage of the fetus and causing the disease.
The impaired migration of ganglion cells in the embryo is the cause of congenital megacolon, so congenital megacolon is hereditary to a certain extent.
There is a clear family history of the disease in most children, with a high mutation rate in the total colon type and the long segment type, and a low mutation rate in the short segment type and those with disseminated disease.