Causes of pressure and pain on both sides of abdomen mainly include intestinal spasm or intestinal flatulence, colitis, intestinal tumor, adnexitis, and peripheral soft tissue injury. 1. Intestinal spasm or intestinal flatulence: because of improper diet, cold, defecation abnormalities can easily cause intestinal flatulence or local intestinal spasm, which can cause this pressure and pain on both sides of the abdomen, usually not accompanied by organic lesions, dietary modification, normal defecation can be relieved. 2. Colitis: including infection and immune system factors, can cause mucosal edema, peripheral exudate stimulation of the peritoneum caused by the pressure and pain on both sides of the abdomen, and some will be accompanied by blood in the stool and change in bowel habits. 3. Intestinal tumor: stimulation of peripheral nerves will cause pressure and pain on both sides of the abdomen, accompanied by weight loss and abnormal defecation, requiring surgical treatment, assisted by radiotherapy when necessary. 4. Female adnexitis: it can also cause pressure and pain on both sides of the abdomen, which can be controlled by anti-inflammatory drugs. 5. Trauma: later will lead to pressure pain on both sides of the abdomen, because of the surrounding soft tissue edema. Pressure and pain on both sides of the abdomen, has not been relieved, we should promptly go to the hospital, improve the examination, clear diagnosis and then be treated accordingly. Drugs should be applied under the guidance of a doctor.