Pientzehuang can generally be taken under the guidance of physician during the period of taking statin, and the specific should follow the doctor’s instruction. Statin drugs are mainly suitable for the treatment of primary hypercholesterolemia and other diseases, and the contraindications of the drugs include those who are allergic to the product, pregnant and lactating women, patients with active liver disease, and those with severe renal function impairment and other conditions. Common adverse reactions include dizziness, headache, nausea, constipation, abdominal pain and so on. Pientzehuang has the efficacy of clearing heat and removing toxins, subduing swelling and relieving pain, cooling blood and removing blood stasis, and it is suitable for diseases caused by heat, toxin and blood stasis, such as acute and chronic viral hepatitis, bruises and all kinds of inflammation. It should be contraindicated in pregnant women and used cautiously in athletes. There are no clear adverse reactions. Statin drugs generally do not have drug effects with Pientzehuang, so when there exists drug indications, Pientzehuang can be taken during statin medication. The use of specific drugs should be guided by specialist physicians and should not be used without authorization.