Fingertip skin wrinkles may be caused by frequent skin soaking or stimulation, may also be hand eczema, need to be specifically analyzed. 1. Skin irritation: hand long-term soaking or stimulation such as the use of alkaline hand sanitizer, etc., hand skin surface layer of protective sebaceous membrane will be destroyed, so the skin waterproof barrier function is impaired, which will lead to the hand skin moisture is easily lost, the fingertips peeling, wrinkled symptoms. 2. Hand eczema: hand eczema can be manifested as dry dark red spots on the hands, localized infiltration hypertrophy, the edge of the clearer, winter often form fissures, which will also cause localized dehydration of the hands, wrinkles. Fingertip skin wrinkles may also be due to the body’s nutritional deficiencies, the lack of certain trace elements, etc. It is recommended to go to the hospital, according to the results of the examination to clarify the cause of the disease, and then follow the doctor’s instructions to do symptomatic treatment.