Often encountered this gastric patients, H. pylori over the limit, quadruple drug every year, every year the indicators are only increasing, began to doubt life, and with Weiler Shu adhere to the conditioning a few months and six months later, the indicators began to slowly decline, the stomach is also comfortable, this is the biggest difference between broad-spectrum bactericidal and probiotic antibacterial, today and everyone science and technology to understand how bacteria resistance to antibiotics is generated? Understanding the mechanism of action of bacteria is the basis for understanding the generation of anti-drugs 1, the production of passivating enzymes Penicillin-resistant strains can produce B-lactamase, the enzyme can specifically open the B-lactam polar ring in the structure of the drug molecule, so that it completely loses its antibacterial activity. 2, the change of drug action target site Bacteria can change the structure and number of proteins of antibiotic action target site, resulting in the change of its effective site of binding with antibiotics, affecting the binding of drugs, so that bacteria escape from antibiotics, such as the change of penicillin binding protein leads to resistance to β-lactam antibiotics. 3, the penetration barrier of antibacterial drugs Antibiotics must enter the interior of the bacteria to reach the target site of action before they can exert antibacterial efficacy. Changes in the cell wall and/or outer membrane permeability of bacteria can form a layer of armor that prevents antibacterial drugs from entering the interior of the bacteria to contact the target site, seriously affecting antibacterial efficacy. 4, active exocytosis mechanism In addition to the formation of armor, bacteria can also be into the body of the antibacterial drugs out of the body. Dozens of bacteria have been found on the outer membrane of a special active drug excretion system, the active excretion of drugs so that the drug concentration in the body of bacteria is insufficient to play antibacterial effects and lead to drug resistance. 5, bacterial biofilm formation biofilm is a unique form of bacterial survival relative to the single dispersed planktonic state of bacterial survival form, is the formation of bacteria to adapt to the environment, it can prevent drug penetration into the bacterial cells. Bacterial biofilm formation can multiply drug resistance and significantly reduce the efficacy of antibacterial drugs. In our body, there are a large number of beneficial bacteria including some special species that can inhibit H. pylori, such as Lactobacillus salivarius and Lactobacillus yohimbe, they could have done to fight against harmful bacteria, but because of long-term stress, environmental dietary toxins, excessive medical treatment, resulting in the gradual disappearance of these beneficial bacteria, allowing harmful bacteria such as H. pylori to multiply and grow wildly, it is necessary to make up for this by exogenous supplementation of Wella It is necessary to make up for this by exogenous supplementation of Weilaxu to regulate this micro-ecological balance, so as to achieve the purpose of healthy stomach.