A small blister on the hand that is clinically common blisters, consider friction, blistering ringworm, sweat herpes and other causes. The main treatment is to remove the cause of the disease, drug treatment, according to the specific cause of the disease to choose the appropriate drugs. 1. caused by friction: if long time doing hand labor, it will cause friction to the skin and blisters, should pay attention to reduce friction. If the blisters are small, they can be absorbed by themselves without special treatment. If they are large, the blisters can be punctured after sterilization so that the liquid inside will flow out, and then erythromycin ointment and fusidic acid cream can be applied locally to prevent infection. 2. Blister ringworm: blister ringworm is a fungal infection, the main manifestations are blisters and itching, etc., you can apply antifungal drugs, such as econazole, ketoconazole, and when the symptoms are more serious, you can take oral terbinafine, itraconazole. 3. Sweat herpes: generally symmetrical on the hands or feet, the cause of the disease is not particularly clear, generally related to allergies, can be used locally boric acid solution to promote the convergence of blisters, if the itching is serious, you can orally ibastine, loratadine, can also be applied locally tretinoin urea ointment, hydrocortisone cream. A small blister on the hand, you should go to the hospital in a timely manner, by the doctor to clarify the cause, standardized treatment, the above drugs should be used under the guidance of the doctor, can not blindly use their own.