Fishy syndrome, also known as trimethylaminuria, is an inborn metabolic disease in which the patient is unable to metabolize trimethylamine in his body, which can be analyzed through clinical manifestations (e.g., fishy odor in breath, urine and sweat) and laboratory tests (e.g., detection of the concentration of trimethylamine (TMA) in the urine), which require specific analysis.
1. Clinical manifestations: patients with ichthyosis are unable to metabolize TMA in their bodies, resulting in the accumulation of the substance in the body, which can be manifested as a ichthyotic odor in the breath, urine, and sweat, and the above symptoms can be aggravated especially after eating seafood, animal offal, and other foods that contain a large amount of TMA.
2. Laboratory tests: the concentration of TMA in the urine of patients with the disease will be significantly higher, which can be analyzed by liquid chromatography, or nuclear magnetic resonance spectroscopy.
The diagnosis of ichthyosis syndrome relies on clinical manifestations and laboratory tests, and after a clear diagnosis, proper treatment and life under the guidance of a doctor is required.