Tooth pain is theoretically possible with alcohol, which means that tooth pain is not directly related to alcohol consumption and that alcohol consumption does not aggravate tooth pain. It certainly does not make it less painful. But clinically it is important to note that patients with toothache are likely to take some medications, mostly antibiotics, usually cephalosporins or nitroimidazoles, both of which may interact with alcohol in what is called a disulfiram-like reaction, which can lead to nausea, vomiting, and in severe cases, even death. So toothache and drinking alcohol are not related, but if a patient takes anti-inflammatory drugs for toothache, it is recommended not to drink alcohol within a week to avoid more serious side effects.