STAT6 positivity refers to a positive immunohistochemistry test for isolated fibrous tumors, which can be helpful in confirming the diagnosis of isolated fibrous tumors.
STAT6 positivity is used as a reference for the differential diagnosis of soft tissue tumors, but if a definitive diagnosis is needed, additional tests are required for analysis.
This substance is a common biological response to receptor-associated kinase phosphorylation of cytokines and growth factors through signal transducers and transcriptional activators, and is expressed in the cytoplasm and nucleus, with genetic translocations occurring in isolated fibrous tumors and angioepidermoid tumors.
Therefore, it is highly sensitive and specific in isolated fibrous tumors and dedifferentiated liposarcoma, and is important for pathological diagnosis.
In addition, angiofibromas, spindle cell lipomas and fibrous histiocytomas are negative for its expression, and it is necessary to go to the hospital to complete the relevant examinations and standardize the treatment under the guidance of doctors.