The difference between premenstrual breast tenderness and pregnancy breast tenderness mainly lies in the following points: 1, the breasts will be tender, but the breast tenderness of pregnancy is soft when touched with the hand, while the premenstrual breasts are relatively hard when touched with the hand.2, when pregnant, under the action of estrogen, the nipple and areola will appear to be coloring, and the nipple is particularly sensitive when touched with the hand, and there will be an erection, which is formed under the action of estrogen. The nipples are particularly sensitive when touched by hand and will have an erection, which is formed under the action of estrogen. Before menstruation, there is no coloring of the nipple and areola, and the nipple is not sensitive, which is the main difference between premenstrual chest pain and pregnancy chest pain. Clinically, if there is a history of menopause, a urine HCG test can be done to find out if you are pregnant.