Coughing with a vague pain in the middle of the chest should beware of reflux esophagitis, tuberculosis and pleurisy. 1. Reflux esophagitis: When the lower esophageal sphincter is structurally damaged or dysfunctional, the reflux of gastric contents causes damage to the esophageal mucosa. When the reflux recurs, the stomach contents irritate the throat, and coughing may occur, causing a vague pain right in the middle of the chest. 2. Tuberculosis: The main germs of tuberculosis include Mycobacterium tuberculosis infection, which has no obvious symptoms at the initial stage, but as the disease develops, it will lead to coughing up sputum, chest pain and chest tightness and shortness of breath, etc., and it will also stimulate the pleural area, causing coughing and hidden pain in the middle of the chest. 3. Pleurisy: caused by bacterial or viral infections, tumors, allergic reactions, chemical and traumatic diseases. Inflammation of the pleura, inflammation stimulation of the pleura reflex cough, the lesion site in the middle of the chest, will also appear hidden pain. There are many other reasons for coughing in the middle of the chest, such as angina, heart attack, gastric ulcer, duodenal ulcer, etc. It is recommended that you go to the hospital in time to clarify the cause of the disease and follow the doctor’s instructions for treatment.