Although medications for hypertension are beneficial, they cannot be used to maintain ideal health and benefit from the prevention and delay of hypertension. 1. Study methods: A total of 26875 black and white participants aged 45 years or older were evaluated and followed up for sudden stroke events. 1. Systolic blood pressure (SBP) was classified as normal (<120 mm Hg), prehypertensive (120C139 mm Hg), hypertensive stage I (140C159 mm Hg), and hypertensive stage II (160 mm Hg+) based on the association between assessment of sudden stroke and SBP. 2. stage II (160 mm Hg+). 2. Graded as 0, 1, 2, 3 or higher according to hypertension medication. 2. Study results: There were 823 stroke events during the 6.3-year follow-up period. Nearly half (46%) of the participants were hypertensive patients who were better treated (SBP <140 mm Hg). In terms of blood pressure, the risk of stroke increased with each additional level of antihypertensive medication required for participants with normal blood pressure, with a risk ratio (HR) of 1.33; 95% confidence interval 1.16 to 1.52. For patients with prehypertension, the HR was 1.15; 95% confidence interval 1.05 to 1.26. For patients with stage 1 hypertension, the HR was 1.22; A patient with better-treated hypertension (SBP <120 mm Hg) who was in antihypertensive drug class 3+ had a slightly higher risk of stroke compared with a patient with stage 1 hypertension who did not receive any treatment (HR, 2.48 vs HR=2.19). Maintaining normal blood pressure by medication alone has profound implications, as does the fact that close to half of the regular participants in the cohort received the relevant treatment as required by the guidelines (SBP <140 mm Hg), but their risk class did not reach normal person levels. Even with good treatment, only some potential benefit exists by preventing and delaying hypertension.