Breast solitary versus multiple refers to single versus multiple breast nodules, which are very common in clinical practice and can be diagnosed by ultrasonography. The presence of a single breast nodule is unlikely to be a malignant nodule, with irregular nodule margins and markedly uneven internal density, or in some patients with burr and lobar changes, further percutaneous fine needle aspiration or surgical excision is recommended, followed by pathological examination. Multiple breast nodules are mostly benign breast-like hyperplasia, which usually cause significant breast swelling and pain in the premenstrual period, and the swelling and pain will be reduced or disappear after the end of menstruation, so there is no need to worry and conservative treatment can be used. Changes in the body’s hormone levels have a great impact on breast nodules, and to a certain extent, there are also family genetic factors, so it is recommended that timely diagnosis and treatment.